Triple-negative Breast Cancer
Triple-negative Breast Cancer
C.S., a premenopausal, 40-year-old, single, Hispanic woman with no children, was diagnosed in April 2006 with invasive adenocarcinoma by needle biopsy of her right breast. Pathology showed estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2/neu-negative—triple-negative breast cancer (TNBC). A magnetic resonance image of the breast showed a 3.5 x 2.5 x 3 cm round mass with irregular margins in the right breast at the 10 o´clock position. The mass was associated with pectoral muscle involvement with marked central necrosis with angiogenesis peripherally. Neoadjuvant treatment started with adriamycin and cyclophosphamide and was to be followed by paclitaxel. C.S. completed four adriamycin and cyclophosphamide treatments, but marked progression of the breast mass on palpation was visibly noted (the lesion was very close to skin surface). One paclitaxel treatment was given with an obvious increase in the size of C.S.´s breast mass; therefore, she was switched to docetaxel. C.S. received three cycles of docetaxel, with the last dose occurring in December 2006. Radiation therapy was planned, but a computed tomography scan showed lung nodules which were positive for metastatic disease. C.S. was referred to the University of Texas M.D. Anderson Cancer Center in Houston for a clinical trial in January 2007 and placed on tipifarnib and gemcitabine. C.S. had issues with cytopenias and infections during the treatment protocol.
C.S., a premenopausal, 40-year-old, single, Hispanic woman with no children, was diagnosed in April 2006 with invasive adenocarcinoma by needle biopsy of her right breast. Pathology showed estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2/neu-negative—triple-negative breast cancer (TNBC). A magnetic resonance image of the breast showed a 3.5 x 2.5 x 3 cm round mass with irregular margins in the right breast at the 10 o´clock position. The mass was associated with pectoral muscle involvement with marked central necrosis with angiogenesis peripherally. Neoadjuvant treatment started with adriamycin and cyclophosphamide and was to be followed by paclitaxel. C.S. completed four adriamycin and cyclophosphamide treatments, but marked progression of the breast mass on palpation was visibly noted (the lesion was very close to skin surface). One paclitaxel treatment was given with an obvious increase in the size of C.S.´s breast mass; therefore, she was switched to docetaxel. C.S. received three cycles of docetaxel, with the last dose occurring in December 2006. Radiation therapy was planned, but a computed tomography scan showed lung nodules which were positive for metastatic disease. C.S. was referred to the University of Texas M.D. Anderson Cancer Center in Houston for a clinical trial in January 2007 and placed on tipifarnib and gemcitabine. C.S. had issues with cytopenias and infections during the treatment protocol.
Source...