Miscellaneous Therapy Is Successful for H. Pylori Eradication
Miscellaneous Therapy Is Successful for H. Pylori Eradication
A total of 122 patients were included in the study and 118 patients completed the treatment protocol; 68% of participants were female. Patients had a mean age of 47.7 ± 12 years. The endoscopic findings were as follows: follicular gastritis in 60 patients (51%), diffuse antral gastritis in 32 (27%), multifocal gastritis in 12 (10%) and peptic ulcer in 14 (12%). The main patient characteristics are described in Table 1. The rate of eradication by miscellaneous therapy in the per protocol (PP) analysis was 94.06% (111/118), with the range of 90–98.3%, at a CI of 95%, and the eradication of the intention-to-treat (ITT) analysis was 91% (111/122) with the range of 86–96% at a CI of 95% (Table 2)
Adherence was confirmed in 96% of cases; 55% (65/118) of patients presented at least one adverse event. Four patients had to be withdrawn from the protocol as a consequence of adverse effects. These were the following: vomiting (1 patient), abdominal pain (1 patient) and nausea (2 patients). Frequencies of adverse effects are described in Table 3. Nausea was the most prevalent one, followed by abdominal pain. Other reported adverse effects were headache, diarrhoea, taste alterations, vomiting and flatulence.
Results
A total of 122 patients were included in the study and 118 patients completed the treatment protocol; 68% of participants were female. Patients had a mean age of 47.7 ± 12 years. The endoscopic findings were as follows: follicular gastritis in 60 patients (51%), diffuse antral gastritis in 32 (27%), multifocal gastritis in 12 (10%) and peptic ulcer in 14 (12%). The main patient characteristics are described in Table 1. The rate of eradication by miscellaneous therapy in the per protocol (PP) analysis was 94.06% (111/118), with the range of 90–98.3%, at a CI of 95%, and the eradication of the intention-to-treat (ITT) analysis was 91% (111/122) with the range of 86–96% at a CI of 95% (Table 2)
Adherence to Treatment and Adverse Events
Adherence was confirmed in 96% of cases; 55% (65/118) of patients presented at least one adverse event. Four patients had to be withdrawn from the protocol as a consequence of adverse effects. These were the following: vomiting (1 patient), abdominal pain (1 patient) and nausea (2 patients). Frequencies of adverse effects are described in Table 3. Nausea was the most prevalent one, followed by abdominal pain. Other reported adverse effects were headache, diarrhoea, taste alterations, vomiting and flatulence.
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