Beef, Microbes in the Gut, and Heart Disease
Beef, Microbes in the Gut, and Heart Disease
Stanley L. Hazen, MD, PhD, isDepartment Chair of Cellular and Molecular Medicine, Section Head of Preventive Cardiology and Rehabilitation, and Vice Chair of Translational Research at the Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Dr. Hazen describes the long-term goal of his laboratory as the understanding of the mechanisms through which inflammation contributes to diseases such as atherosclerosis and asthma. Current research programs are focused on the role of myeloperoxidase in promoting oxidant stress in vivo, and its participation in cardiovascular diseases; HDL structure and function; the roles of peroxidases and tobacco exposure in airway remodeling in asthma; and the role of intestinal microbiota in cardiometabolic disease. All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench to bedside, including basic/genetic, cellular, animal model, and human clinical investigations.
Dr. Hazen was lead investigator and senior author of:
Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576-585.
Tang WHW, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368:1575-1584.
An Expert Interview With Stanley L. Hazen, MD, PhD
About the Interviewee
Stanley L. Hazen, MD, PhD, isDepartment Chair of Cellular and Molecular Medicine, Section Head of Preventive Cardiology and Rehabilitation, and Vice Chair of Translational Research at the Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Dr. Hazen describes the long-term goal of his laboratory as the understanding of the mechanisms through which inflammation contributes to diseases such as atherosclerosis and asthma. Current research programs are focused on the role of myeloperoxidase in promoting oxidant stress in vivo, and its participation in cardiovascular diseases; HDL structure and function; the roles of peroxidases and tobacco exposure in airway remodeling in asthma; and the role of intestinal microbiota in cardiometabolic disease. All research projects rely heavily on chemical and analytical methods to identify specific reactions/products, their mechanisms of formation, and their use as probes to elaborate pathways responsible for disease. Research efforts in each program span from bench to bedside, including basic/genetic, cellular, animal model, and human clinical investigations.
The Studies
Dr. Hazen was lead investigator and senior author of:
Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19:576-585.
Tang WHW, Wang Z, Levison BS, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368:1575-1584.
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