Summary Points: CSF Biomarkers in Parkinsonism

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  Aβ42 has a role in predicting cognitive decline in Parkinson's disease (PD)
  
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  t-α-Syn: most promising marker; differentiates synucleinopathies from other neurodegenerative diseases and controls but is not specific
  
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  t-tau and p-tau: inconsistent data, can help differentiate PD from AD and can be useful in combination with other markers
  
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  NF-L: useful in differentiating PD from atypical parkinsonian conditions
  
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  4R-tau: possible marker of disease progression in PSP
  
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  DJ1: potential role in discriminating MSA from PD
  
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  Oxidative stress/inflammatory/metabolic markers: promising initial results, requiring further validation