What It Is

• Pick's disease involves brain cells that are shrinking because of a protein buildup. Behavior changes are the first indicator that something is very wrong.
  
  

Rudeness/Impatience

• One indication that Pick's disease might be what is affecting you or your loved one is a sudden change in behavior. Rude, impatient behavior that was not an issue before shows itself in Pick's victims.
  
  

Withdrawal/Lack of Attention to Self Care

• Withdrawal and problems keeping up with personal hygeine can be signs that one has Pick's disease.
  
  

Moodiness/Lack of Empathy

• People who normally were caring, reasonable human beings become grumpy or very sad quickly and easily. Empathy for others often disappears.
  
  

Communication and Comprehension

• Helpguide.org has stated that Pick's patients will begin to have trouble communicating. Simple words will vanish from their vocabulary. They will also have trouble understanding what others are saying to them.
  
  

A Bright Sign

• Although Pick's disease causes irreversible mental deterioration, the University of California/San Francisco Medical Center's Memory and Aging Center has discovered some patients who have found new talents for music and art. The patients who experienced that had lost most brain cells in the left frontal lobe, where language is controlled.