Low Serum Magnesium Concentrations and PVCs in Obese Adults With T2DM
Low Serum Magnesium Concentrations and PVCs in Obese Adults With T2DM
This study provides evidence that T2DM is an important effect modifier of the association between sMg and ventricular ectopy, with significant reductions in PVC prevalence across the sMg gradient in adults with T2DM. Diabetic status, but not MetS, was a major determinant of very low sMg levels in this population. PVC risk was particularly elevated in diabetic adults with hypomagnesemia, suggesting that future interventions to increase sMg concentrations among adults with T2DM may confer protection against ventricular arrhythmias. As hypomagnesemia is an under-diagnosed electrolyte abnormality common in T2DM, appropriately powered randomized controlled clinical trials are required to evaluate the potential of Mg to reduce arrhythmias and cardiovascular risk.
Conclusions
This study provides evidence that T2DM is an important effect modifier of the association between sMg and ventricular ectopy, with significant reductions in PVC prevalence across the sMg gradient in adults with T2DM. Diabetic status, but not MetS, was a major determinant of very low sMg levels in this population. PVC risk was particularly elevated in diabetic adults with hypomagnesemia, suggesting that future interventions to increase sMg concentrations among adults with T2DM may confer protection against ventricular arrhythmias. As hypomagnesemia is an under-diagnosed electrolyte abnormality common in T2DM, appropriately powered randomized controlled clinical trials are required to evaluate the potential of Mg to reduce arrhythmias and cardiovascular risk.
Source...