Anticonvulsant-Induced Cutaneous Reactions Present a Challenge
Anticonvulsant-Induced Cutaneous Reactions Present a Challenge
Cutaneous drug reactions (CDRs) to anticonvulsants are relatively uncommon but represent one of the most challenging aspects of optimising the clinical care of patients with epilepsy or mood disorders. These reactions are idiosyncratic and there is a lack of consensus on their reporting and systematic classification. Exanthematous (morbilliform) reactions are the most common.
Most CDRs are mild, but severe and life-threatening reactions [e.g. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), anticonvulsant hypersensitivity syndrome] also occur. Management of anticonvulsant-related CDRs includes withdrawal of the offending drug and supportive and/or arrestive therapy as appropriate.
Cutaneous drug reactions (CDRs) to anticonvulsants are relatively uncommon but represent one of the most challenging aspects of optimising the clinical care of patients with epilepsy or mood disorders. These reactions are idiosyncratic and there is a lack of consensus on their reporting and systematic classification. Exanthematous (morbilliform) reactions are the most common.
Most CDRs are mild, but severe and life-threatening reactions [e.g. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), anticonvulsant hypersensitivity syndrome] also occur. Management of anticonvulsant-related CDRs includes withdrawal of the offending drug and supportive and/or arrestive therapy as appropriate.
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