HCV Vaccine Development in HIV-HCV Coinfection
HCV Vaccine Development in HIV-HCV Coinfection
Despite the recent and encouraging advances in HCV treatment using HCV protease inhibitors, the development of vaccine strategies to protect from HCV infection or prevent HCV persistence is vital. Elaborating such a vaccine is met with numerous difficulties, including the extreme heterogeneity of the virus and its capacity to evade the host immune response in multiple ways. Immunogens and vaccination protocol therefore have to bypass immune evasion by eliciting a strong immune response against the multiple HCV genotypes and quasispecies. The design of such strategies is a crucial step in HCV vaccine development. Several vaccine approaches were assessed in mice and chimpanzees, but only a few have progressed into human trials (registered on.
HCV Vaccine Approaches: Current Status
Despite the recent and encouraging advances in HCV treatment using HCV protease inhibitors, the development of vaccine strategies to protect from HCV infection or prevent HCV persistence is vital. Elaborating such a vaccine is met with numerous difficulties, including the extreme heterogeneity of the virus and its capacity to evade the host immune response in multiple ways. Immunogens and vaccination protocol therefore have to bypass immune evasion by eliciting a strong immune response against the multiple HCV genotypes and quasispecies. The design of such strategies is a crucial step in HCV vaccine development. Several vaccine approaches were assessed in mice and chimpanzees, but only a few have progressed into human trials (registered on.
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